Ass.-Prof. Mag. pharm. Dr. Sophia Khom

University of Vienna, Faculty of Life Sciences
Department of Pharmaceutical Sciences
Division of Pharmaceutical Chemistry
Althanstrasse 14, 2E 360
A-1090 Vienna, Austria

Tel. +43-1-4277-55035
email: sophia.khom@univie.ac.at

Curriculum Vitae: PDF

Research Interests:
• Alcohol use disorder
• Synaptic transmission (GABA and glutamate)
• Neuropeptides
• Amygdala
• Pharmaceutical Bioanalysis

 

 

Teaching:
321015 VO Pathophysiologie - B8
• 321023 VO Trenn- und Analysemethoden org. Arzneistoffe inkl. bioanalyt. Methoden - B12
322023 VU Ausgewählte Kapitel aus der pharmakologischen Forschung - M13
321037 VU Pharmazeutische Wissenschaften - B20

Complete Publication RecordPDF

Most important Publications:

  1. Importance of sex and trauma context on circulating cytokines and amygdalar GABAergic signaling in a comorbid model of posttraumatic stress and alcohol use disorders.
    Steinman MQ, Kirson D, Wolfe SA, Khom S, D'Ambrosio SR, Spierling Bagsic SR, Bajo M, Vlkolinský R, Hoang NK, Singhal A, Sureshchandra S, Oleata CS, Messaoudi I, Zorrilla EP, Roberto M. 
    Mol Psychiatry. 2020 Oct 21. doi: 10.1038/s41380-020-00920-2, IF: 12.455
  2. Synthetic, Mechanistic, and Biological Interrogation of Ginkgo biloba Chemical Space En Route to (-)-Bilobalide. 
    Demoret RM, Baker MA, Ohtawa M, Chen S, Lam CC, Khom S, Roberto M, Forli S, Houk KN, Shenvi RA.
    J Am Chem Soc. 2020 Oct 28;142(43):18599-18618. doi: 10.1021/jacs.0c08231, IF: 14.612
  3. Alcohol Dependence and Withdrawal Impair Serotonergic Regulation of GABA Transmission in the Rat Central Nucleus of the Amygdala.
    Khom S, Wolfe SA, Patel RR, Kirson D, Hedges DM, Varodayan FP, Bajo M, Roberto M.
    J Neurosci. 2020 Sep 2;40(36):6842-6853. doi: 10.1523/JNEUROSCI.0733-20.2020, IF: 5.673
  4. Microglia Control Escalation of Drinking in Alcohol-Dependent Mice: Genomic and Synaptic Drivers. 
    Warden AS*, Wolfe SA*, Khom S*, Varodayan FP*, Patel RR, Steinman MQ, Bajo M, Montgomery SE, Vlkolinsky R, Nadav T, Polis I, Roberts AJ, Mayfield RD, Harris RA, Roberto M.
    Biol Psychiatry. 2020 Dec 15;88(12):910-921. doi: 10.1016/j.biopsych.2020.05.011,
    IF: 11.501, * equal contribution
  5. Alcohol dependence potentiates substance P/neurokinin-1 receptor signaling in the rat central nucleus of amygdala.
    Khom S*, Steinkellner T, Hnasko TS, Roberto M*
    Sci Adv. 2020 Mar 18;6(12):eaaz1050. doi: 10.1126/sciadv.aaz1050. eCollection 2020 Mar.
    IF: 14.094 ,* corresponding authors 
  6. The Role of the Central Amygdala in Alcohol Dependence. 
    Roberto M, Kirson D, Khom S.
    Cold Spring Harb Perspect Med. 2021 Feb 1;11(2):a039339. doi: 10.1101/cshperspect.a039339,
    IF: 6.000 
  7. Analysis of β-Subunit-dependent GABAA Receptor Modulation and Behavioral Effects of Valerenic Acid Derivatives.
    Khom S*, Hintersteiner J, Luger D, Haider M, Pototschnig G, Mihovilovic MD, Schwarzer C*, Hering S.
    J Pharmacol Exp Ther. 2016 Jun;357(3):580-90. doi: 10.1124/jpet.116.232983.
    IF: 3.389, * corresponding authors
  8. Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site-directed mutagenesis.
    Luger D, Poli G, Wieder M, Stadler M, Ke S, Ernst M, Hohaus A, Linder T, Seidel T, Langer T, Khom S*, Hering S.
    Br J Pharmacol. 2015 Nov;172(22):5403-13. doi: 10.1111/bph.13329,
    IF: 7.73, * corresponding author
  9. Valerenic acid derivatives as novel subunit-selective GABAA receptor ligands - in vitro and in vivo characterization.
    Khom S*, Strommer B*, Ramharter J, Schwarz T, Schwarzer C, Erker T, Ecker GF, Mulzer J, Hering S.
    Br J Pharmacol. 2010 Sep;161(1):65-78. doi: 10.1111/j.1476-5381.2010.00865.x,
    IF: 7.73, * Equal contribution
  10. Valerenic acid potentiates and inhibits GABA(A) receptors: molecular mechanism and subunit specificity.
    Khom S, Baburin I, Timin E, Hohaus A, Trauner G, Kopp B, Hering S.
    Neuropharmacology. 2007 Jul;53(1):178-87. doi: 10.1016/j.neuropharm.2007.04.018, IF:4.431